By Julius A. Vida (Eds.)
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Extra resources for Anticonvulsants
R K Ra O O II II /CH—C—N—C—NH—R4 I R3 1. Phenacemide Phenylacetylurea is a straight-chain anticonvulsant compound with significant efficacy for generalized tonic and/or clonic seizures, absence seizures, and many partial seizures. Unfortunately, it is also one of the most toxic anticonvulsant drugs. The principal toxic reactions that occur frequently involve mood changes such as depression, irritability, agitation, and aggressive or violent behavior. Psychotic reactions also occur. Phenacemide has also Brian B.
1975). The anticonvulsant activity of the benzodiazepines may reflect multiple effects at several levels in the central nervous system. Regardless of their potent activity in experimental models, their clinical usefulness is impeded by toxicity, tolerance, and, for some, rapid metabolism and distribution effects. Chlordiazepoxide is used principally as a tranquilizing agent.
With these doses in the presence of diphenylhydantoin significant concentrations of phénobarbital accumulate, usually in the range of 2040/xg/ml of serum. To a great extent, such large amounts of phénobarbital obscure the anticonvulsant activity of primidone itself. Since this activity has not been well documented in previous literature, a typical case report illustrating the point follows. ) A 42-year-old black man with a history of generalized seizures in infancy following head trauma was well until the age of 30 years.
Anticonvulsants by Julius A. Vida (Eds.)