New PDF release: Bipolar Disorders: Basic Mechanisms and Therapeutic

By Jair C. Soares, Allan H. Young

ISBN-10: 0849398975

ISBN-13: 9780849398971

ISBN-10: 142002115X

ISBN-13: 9781420021158

Responding to the explosion of study at the pathophysiology and administration of bipolar sickness, this thoroughly revised moment variation spans easy mechanisms, neuroimaging, viral etiology, neurofactors, present remedy implications, and smooth theories of the neurobiology of bipolar affliction to face because the such a lot authoritative reference in this debilitating . Written and edited via across the world lauded specialists within the box, this resource covers an expansive array of issues together with genetic and causal components, neuroendocrinology, neurotransmitters and sign transduction pathways, neuroimaging and neurorecognition, and clients for brand new remedy improvement.

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Extra resources for Bipolar Disorders: Basic Mechanisms and Therapeutic Implications, 2nd edition (Medical Psychiatry)

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Altogether, the authors suggest that modifications of the GRK genes (using transgenic techniques in mice for example) may result in a better model for the disease that will be hypothesis-driven. Other genes and intracellular pathways had been implicated during the last decade in bipolar disorder and indeed some of these ideas can be used to create hypothesis-driven models with strong construct validity. Manipulations of many of these tentative genes proteins and intracellular pathways in animals do indeed result in behaviors that resemble bipolar disorder and were recently summarized in a review paper (44).

Biol Psychiatry 1997; 41(4):438– 451. 58. Kalynchuk LE, Pinel JP, Treit D, et al. Persistence of the interictal emotionality produced by long-term amygdala kindling in rats. Neuroscience 1998; 85(4): 1311 – 1319. 59. Machado-Vieira R, Kapczinski F, Soares JC. Perspectives for the development of animal models of bipolar disorder. Prog Neuropsychopharmacol Biol Psychiatry 2004; 28(2):209–224. 60. Shih RA, Belmonte PL, Zandi PP. A review of the evidence from family, twin and adoption studies for a genetic contribution to adult psychiatric disorders.

40. Redrobe JP, Bourin M. Evidence of the activity of lithium on 5-HT1B receptors in the mouse forced swimming test: comparison with carbamazepine and sodium valproate. Psychopharmacology (Berl) 1999; 141(4):370–377. 41. Bersudsky Y, Shaldubina A, Belmaker RH. Lithium’s effect in forced-swim test is blood level dependent but not dependent on weight loss. Behav pharmacol 2007; 18(1):77– 80. 42. Einat H, Yuan P, Gould TD, et al. The role of the extracellular signal-regulated kinase signaling pathway in mood modulation.

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Bipolar Disorders: Basic Mechanisms and Therapeutic Implications, 2nd edition (Medical Psychiatry) by Jair C. Soares, Allan H. Young


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