By Hari G. Garg, Charles A. Hales
It used to be most likely the French chemist Portes, who first pronounced in 1880 that the mucin within the vitreous physique, which he named hyalomucine, behaved in a different way from different mucoids in cornea and cartilage. 54 years later Karl Meyer remoted a brand new polysaccharide from the vitreous, which he named hyaluronic acid. this present day its reputable identify is hyaluronan, and modern day learn in this polysaccharide keeps to develop.
Expertly written via prime scientists within the box, this booklet offers readers with a extensive, but specific assessment of the chemistry of hyaluronan, and the function it performs in human biology and pathology. Twenty-seven chapters current a chain prime from the chemistry and biochemistry of hyaluronan, through its position in a number of pathological stipulations, to changed hylauronans as strength healing brokers and eventually to the sensible, structural and organic houses of hyaluronidases. Chemistry and Biology of Hyaluronan covers the various attention-grabbing elements of this attention-grabbing molecule, and all chapters are meant to arrive the broader examine neighborhood. * accomplished examine the chemistry and biology of hyaluronans * sential to Chemists, Biochemists and clinical researchers * vast but distinctive evaluation of this speedily growing to be learn quarter
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Additional info for Chemistry and Biology of Hyaluronan
Scott JE, Tigwell MJ. Periodate oxidation and the shapes of glycosaminoglycuronans in solution. Biochem J 1978; 173:103 –114. 19. Morris ER, Rees DA, Welsh EJ. Conformation and dynamic interactions in HA solutions. J Mol Biol 1980; 138:383 – 400. 20. Wik KO, Comper WD. Hyaluronate diffusion in semi-dilute solutions. Biopolymers 1982; 21:583 –599. 21. Sheehan JK, Atkins EDT. X-ray fiber diffraction study of the conformational changes in hyaluronic acid induced in the presence of sodium, potassium and calcium cations.
Isolation of oligosaccharides enzymatically produced from hyaluronic acid. J Biol Chem 1954; 208:417– 429. Methods for Analysis of Hyaluronan and Its Fragments 37 13. Fessler JH, Fessler LI. Electron microscopic visualization of the polysaccharide hyaluronic acid. Proc Natl Acad Sci USA 1966; 56:141 –147. 14. Comper WD, Laurent TC. Physiological function of connective tissue polysaccharides. Physiol Rev 1978; 58:255– 315. 15. Hardingham TE, Muir H. The specific interaction of hyaluronic acid with cartilage proteoglycans.
Sasisekharan The physical properties of hyaluronan as a high molecular weight polymer account for its role as an essential structural component of the ECM. However, in order to better understand its role in interaction with different proteins, low molecular weight hyaluronan oligosaccharides have been very useful. Using hyaluronan oligomers of defined sizes, Lesley et al. were able to clearly demonstrate the role of cooperativity in the binding of HA by cell surface CD44 (29). Furthermore, hyaluronan decasaccharides were the minimum size oligosaccharides required to displace hyaluronan from CD44 on keratinocytes (30).
Chemistry and Biology of Hyaluronan by Hari G. Garg, Charles A. Hales