By Ganapathy Subramanian
Completely revised, with both totally new or thoroughly up to date contents, this can be a functional handbook for the small and large-scale education of enantiomerically natural items. the result's an important source for assembly the top purity criteria within the manufacture of chiral prescribed drugs, foodstuff ingredients and comparable compounds. all of the methods lined listed here are hugely correct to fashionable production and quality controls schemes within the pharmaceutical and biotech industries, addressing the more and more vital factor of drug protection in view of more durable regulatory criteria around the globe.
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Additional info for Chiral Separation Techniques: A Practical Approach
The Food and Drug Administration (FDA) and other authorities put forward certain regulations on the marketing of racemic drugs and pharmaceuticals, which resulted in an increased demand for chiral separation methods. 0 billion in 2009 . In addition to medical science, the concept of chirality is also important in the environmental field. Many xenobiotics and pollutants are chiral in nature and two enantiomers may have different toxicities . Sometimes, degradation of some achiral pollutants results in chiral toxic metabolites.
Chem. 2000, 72, 1767–1780. Joyce K. , Jones A. , Scott R. , Biddlecombe R. , Pleasance S. Rapid Commun. Mass Spectrom. 1998, 12, 1899–1910. , Flieger M. J. Chromatogr. A 1999, 844, 137–147. Scott R. P. , Beesley T. E. Analyst 1999, 124, 713–719. , Armstrong D. W. J. Chromatogr. A 2002, 731, 89–107. , He B. L, Beesley B. E. J. Chromatogr. A 2004, 1060, 205–214. , Arm- 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 strong D. W. J. Chromatogr. A 1996, 731, 123–137. , Armstrong D. W. J. Chromatogr. A 1998, 793, 283–296.
Among various polymers of polysaccharides, derivatives of amylose and cellulose in particular were synthesized as the gave the best results [23, 26]. The most useful and successful derivatives of cellulose and amylose are triesters and tricarbamates [23, 26, 30]. Okamoto et al.  prepared several triesters and tricarbamates of cellulose and amylose derivatives, among which triphenylcarbamate derivatives of amylose and cellulose have been most widely investigated polysaccharide phases with respect to chiral resolution and mechanisms [32–35].
Chiral Separation Techniques: A Practical Approach by Ganapathy Subramanian