By Willi Bannwarth, Berthold Hinzen, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
The hot variation of this practice-oriented guide gains completely up-to-date contents, together with fresh advancements in parallel synthesis. a brand new bankruptcy on screening enhances the evaluate of combinatorial technique and artificial tools. "Experimental information and whole response facts ... are a continuing topic operating via this work". (Angewandte Chemie). "Recommended to rookies within the box of combinatorial chemical synthesis as a result of its huge scope". (Journal of the yank Chemical Society). Read more... Purification ideas in high-speed solution-phase synthesis / Steffen Weinbrenner, C. Christoph Tzschucke -- Linkers for solid-phase natural synthesis (SPOS) and combinatorial ways on reliable helps / Willi Bannwarth -- Cyclative cleavage : a flexible thought in solid-phase natural chemistry / Josef Pernerstorfer -- C-C bond-forming reactions / Wolfgang K.-D. Brill, Gianluca Papeo -- Combinatorial synthesis of heterocycles / Eduard R. Felder, Andreas L. Marzinzik -- Polymer-supported reagents : practise and use in parallel natural synthesis / Berthold Hinzen, Michael G. Hahn -- Encoding suggestions for combinatorial libraries / Berthold Hinzen -- Automation and units for combinatorial chemistry and parallel natural synthesis / Christian Zechel -- Computer-assisted library layout / Andreas Dominik -- Assays for high-throughput screening in drug discovery / Christian M. Apfel, Thilo Enderle
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Extra resources for Combinatorial chemistry : from theory to application
The dichloromethane or chloroform phase can pass through the frit, while the aqueous phase remains on top of the filter. Another separation method involves cooling of the organic/aqueous phase to –20 °C in deep-well plates in the presence of pins. After the freezing process, the aqueous phase can be removed as ice attached to the array of pins while the organic phase remains in the deep-well plate. By this so-called “lollipop” method, 96 aqueous/organic mixtures can be easily separated . 3 Fluorous Biphasic Systems A different extractive work-up is based on fluorous biphasic systems.
The combined filtrate and washings were concentrated to dryness in vacuo to yield product 52. 2 Resin Capture As mentioned above, the second PASP strategy for purifying a crude reaction mixture after a synthesis is to separate the desired product by selective covalent derivatization with a functionalized resin followed by filtration and rinsing. After the formation of the product in solution, it reacts selectively with a solid support while impurities and unreacted substrate remain in solution and are washed away.
Helv. Chim. Acta 87, 2882–2889 (2004). 34 Curran D. , Tetrahedron 57, 5243–8253 (2001). , Curran D. , Science 291, 1766–1769 (2001). 36 Gayo L. , Suto M. , Tetrahedron Lett. 38, 513–516 (1997). 37 Suto M. , Gayo-Fung L. , Palanki M. S. , Tetrahedron 54, 4141–4150 (1998). Siegel M. , Hahn P. , Dressman B. , Fritz J. , Grunwell J. , Kaldor S. , Tetrahedron Lett. 38, 3357–3360 (1997). Lawrence R. , Biller S. , Fryszman O. , Poss M. , Synthesis 553–558, (1997). Shuker A. , Siegel M. , Matthews D.
Combinatorial chemistry : from theory to application by Willi Bannwarth, Berthold Hinzen, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers