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By M. Metzler

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Extra resources for Endocrine Disruptors - Part I [Hbk of Environmental Chem Vol 3, Part L]

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3 Alterations in Sex Differentiation Disruption of male sex differentiation and development in utero is not lethal. Deviations in sex development of the newborn have been observed in wildlife and humans populations. Genetic sex determined at fertilization results in the expression of the SRY gene on the Y chromosome [19] which directs differentiation of the indifferent gonad into testes that produce testosterone, which in turn induces differentiation of the male internal ducts and external genitalia [20].

6 Peptide Probes Ligand binding to a steroid hormone receptor causes a conformational change in that receptor. A recent publication described a method that used affinity-selected, phage-displayed peptides to probe the conformational changes that occur with the ER after binding various ligands [82]. In this manuscript it was demonstrated that different peptide-binding surfaces on the ER are exposed in response to binding different ligands. To perform a phage display assay ER is immobilized on 96-well plates and then incubated for 1 h with test compound (Fig.

Predefined assay performance criteria would then be used to assess the ability of the individual labs and their specific protocols to conduct adequately ED studies. This review focuses on the molecular mechanisms by which environmental antiandrogens inhibit androgen activity using as examples specific environmental antiandrogens discovered to date. Androgen action and the role of androgens in normal sex differentiation and development are discussed. Data indicating additive interactions at the level of the AR are presented as examples of mixtures acting through common mechanisms, a topic important to the characterization of relative risk to human and ecological health.

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Endocrine Disruptors - Part I [Hbk of Environmental Chem Vol 3, Part L] by M. Metzler


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