By Akira Sawa
It is a well-established foreign sequence that examines significant parts of uncomplicated and medical learn inside neuroscience (as good as rising and promising subfields): neuroanatomy, neurophysiology, neuroimaging, neurobiology, neuropharmacology, neuroendocrinology, neuropathology, neuropsychiatry, neurobehavior. This quantity offers a radical remedy of gene versions of schizophrenia, proposing articles from prime participants during this vital quarter.
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Extra info for Genetic Models of Schizophrenia
1995). Ligand-regulated site-speciﬁc recombination. Proceedings of the National Academy of Sciences of the United States of America, 92, 5940–5944. Mallo, M. (2006). Controlled gene activation and inactivation in the mouse. Frontiers in Bioscience, 11, 313–327. , & Weinberger, D. R. (2000). The neurodevelopmental hypothesis of schizophrenia: Following a trail of evidence from cradle to grave. Development and Psychopathology, 12(3), 501–527. McKinney, B. , Schneider, J. , Schafer, G. , Lowing, J.
1982; Hillen and Berens, 1994). The system that is widely used in mouse genetic models is bi-transgenic model that includes two genetic cassettes (Fig. 1). The socalled response cassette consists of the target gene linked to a hybrid promoter that contains tandem repeats of tetO and a minimal promoter to express the gene. , 1991). The most popular versions of the tet system employ a TetR derivative that has been modiﬁed to serve as a transcriptional activator by fusing TetR with the herpes simplex virus protein VP16 (16) (Fig.
1998; Mallo, 2006). Although the components and structure of each system can be different, the principles of these systems are similar. For an inducible transgenic system to work properly, three parts are needed, a regulatory unit, a responsive element linked to a target gene, and an induction agent. In an ideal system, expression of the transgene can be turned on or off quickly and reversibly by an external inducer. Combined with a tissue- or cell-speciﬁc promoter, the inducible system provides temporal and spatial control over the expression of the transgene.
Genetic Models of Schizophrenia by Akira Sawa