By Ralph A. Bradshaw, Edward A. Dennis
* comprises over 350 chapters of entire assurance on phone signaling
* comprises dialogue on themes from ligand/receptor interactions to organ/organism responses
* offers uncomplicated, well-illustrated, respected content material by way of specialists within the field
Handbook of mobilephone Signaling, Three-Volume Set, 2e, is a accomplished paintings overlaying all features of intracellular sign processing, together with extra/intracellular membrane receptors, sign transduction, gene expression/translation, and cellular/organotypic sign responses. the second one version is an updated, extended reference with every one part edited via a famous specialist within the box. Tabular and good illustrated, the instruction manual will function an in-depth reference for this advanced and evolving box. guide of telephone Signaling, 2/e will entice a vast, cross-disciplinary viewers attracted to the constitution, biochemistry, molecular biology and pathology of mobile effectors.
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Extra info for Handbook of Cell Signaling
Rev. Neuroscie. 24, 551–600. 7. Hamburger, V. (1989). The journey of a neuroembryologist. Annu. Rev. Neurosci. 12, 1–12. 8. Levi-Montalcini, R. (1987). The nerve growth factor 35 years later. Science 237, 1154–1162. 9. Angeletti, R. H. and Bradshaw, R. A. (1971). Nerve growth factor from mouse submaxillary gland: amino acid sequence. Proc. Natl. Acad. Sci. USA 68, 2417–2420. 10. Savage, C. , and Cohen, S. (1972). The primary structure of epidermal growth factor. J. Biol. Chem. 247, 7612–7621. 11.
In particular, Sutherland and colleagues  were redeﬁning hormones as messengers and their ability to produce second messengers. This was, of course, based primarily on the identiﬁcation of cyclic AMP (cAMP) and its production by a number of classical hormones. However, it also became clear that not all hormones produce this second messenger nor was it stimulated by any of the growth factors known at that time. This enigma remained unresolved for quite a long time until tyrosine kinases were identiﬁed, and it was shown, ﬁrst with the EGF receptor , that these entities were responsible for the signal transduction for many of those hormones and growth factors that did not stimulate the production of cAMP.
2001). Viktor Hamburger and Rita Levi-Montalcini: the path to the discovery of nerve growth factor. Annu. Rev. Neuroscie. 24, 551–600. 7. Hamburger, V. (1989). The journey of a neuroembryologist. Annu. Rev. Neurosci. 12, 1–12. 8. Levi-Montalcini, R. (1987). The nerve growth factor 35 years later. Science 237, 1154–1162. 9. Angeletti, R. H. and Bradshaw, R. A. (1971). Nerve growth factor from mouse submaxillary gland: amino acid sequence. Proc. Natl. Acad. Sci. USA 68, 2417–2420. 10. Savage, C.
Handbook of Cell Signaling by Ralph A. Bradshaw, Edward A. Dennis