By George Lunn
An integral source for busy researchersYour time is valuable-too worthy to spend searching throughout the technical literature looking for the correct HPLC assay recommendations in your tasks. With HPLC equipment for lately authorized prescribed drugs, you are going to fast determine and reflect the right methods to your venture wishes, with no need to consult unique resource guides. extra of a while can then be spent within the lab, no longer the library.Covering the suitable global literature via 2003, this booklet selections up the place Dr. Lunn's acclaimed HPLC tools for Pharmaceutical research left off. It hands you with validated HPLC assay thoughts for countless numbers of newly authorized medicinal drugs, in addition to medications for which assay tools have been just recently built. Combining targeted descriptions of systems with specifically annotated references, this sensible guide provides you:* HPLC tools for 390 in general prescribed pharmaceutical compounds* quite a few methods for every drug indexed together-making it effortless to mix 'n match for custom designed techniques* tools for medicines in organic fluids and for bulk and formulated medicinal drugs* Chemical buildings, molecular weights and formulation, and CAS Registry Numbers* Cross-references to The Merck Index* Retention instances of alternative medications that may be assayed utilizing an analogous tools
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Extra resources for HPLC Methods for Recently Approved Pharmaceuticals
B, 1996, 683, 143–154. ; Cini, M. A, 2001, 905, 345–350. ; Durand, A. In vitro metabolism of three major isomers of retinoic acid in rats. , 1997, 25, 637–646. ; Ishii, H. B, 2001, 757, 365–368. J. B, 2003, 798, 309–316. L. , 1997, 25, 27–32. ; Burvenich, C. Acta, 2002, 468, 237–244. ; Bucheli, F. B, 1997, 700, 31–47. ; Kagechika, H. Determination of endogenous levels of retinoic acid isomers in type II diabetes mellitus patients. , 2002, 25, 1268–1271. 41 CAS Registry No: 584-79-2 Merck Index: 13, 256 H3C CH3 H3C H3C O O O H3C CH2 SAMPLE Matrix: fruit, vegetables Sample preparation: Prepare a cleanup column by placing 4 g Florisil, 1 g activated charcoal, and a 20 mm layer of anhydrous sodium sulfate in a 400 × 10 glass column, wash with 40 mL toluene, wash with 40 mL toluene:MeCN 99:1.
1 mL plasma or serum with 1 mL buffer containing 10 ng/mL IS, vortex, add 2 mL to the SPE cartridge, wash with 2 mL buffer, dry with nitrogen for 30 s, wash with 2 mL MeCN, elute with two 2 mL aliquots of MeCN:buffer 90:10. Evaporate the eluate to dryness under a stream of nitrogen at 40◦ , reconstitute the residue with 300 µL mobile phase, vortex, inject a 200 µL aliquot. R. B, 1996, 678, 261–267. 57 CAS Registry No: 51022-69-6 Merck Index: 13, 387 O CH3 HO O CH3 F H O H O SAMPLE Matrix: formulations Sample preparation: Condition a 3 mL 500 mg Megabond MF C18 SPE cartridge (Varian) with 3 mL MeOH and 3 mL water.
Gradient. MeCN:water from 25:75 to 90:10 over 30 min, maintain at 90:10 for 10 min. ; Tonelli, D. Acta, 2002, 457, 187–198. SAMPLE Matrix: formulations Sample preparation: Mix 1 g of a topical product, 5 mL 100 mM pH 4 citrate buffer saturated with NaCl, and 10 mL ethyl acetate, shake vigorously by hand to ensure that no large clumps stick to the tube, mix with the tube on its side on an oscillating shaker for 15 min. Remove the upper ethyl acetate layer and wash with citrate buffer as before. Dry the ethyl acetate over anhydrous sodium sulfate and evaporate to dryness.
HPLC Methods for Recently Approved Pharmaceuticals by George Lunn