Download e-book for iPad: Infections Causing Human Cancer by Harald zur Hausen

By Harald zur Hausen

ISBN-10: 3527310568

ISBN-13: 9783527310562

ISBN-10: 3527609296

ISBN-13: 9783527609291

Written via the Nobel Prize Laureate in body structure or medication 2008In the Nineteen Seventies, the writer of this paintings and his co-workers first and foremost chanced on Epstein-Barr virus DNA in Burkitt’s lymphomas and nasopharyngeal melanoma and made the relationship among HPV an infection and cervical melanoma. It was once additionally in this interval and as a consequence that scientists around the globe stumbled on tumor-inducing micro organism, viruses, parasites, and protozoa, starting up solely new clients for the prevention and remedy of infection-induced melanoma by means of vaccination.Adopting a unifying idea and a constant constitution for the person chapters, Professor zur Hausen presents an intensive and finished review on cancer-inducing infective agents — viruses, micro organism and parasites — and their corresponding remodeling capacities and mechanisms. He doesn't disguise the constitution and molecular biology of the brokers awarded in nice element, yet quite concentrates on these elements that hyperlink the respective brokers to human oncogenesis. As such, an in depth bibliography after every one bankruptcy allows extra reports at the subject.With a bankruptcy on Helicobacter written by means of James Fox and his colleagues at Harvard collage, this can be a useful and instructive reference for all oncologists, microbiologists and molecular biologists operating within the sector of infections and cancer. 

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Sample text

Bring indisputable evidence for or against the cause and effect hypothesis and none can be required as a sine qua non”. In 1990, Evans and Mueller based their criteria for an etiological relationship between virus infection and tumor development more on immunological aspects, in part influenced by a previous publication by Rivers (1937). They subdivided their “. . guidelines for relating a putative virus to human cancers” into an epidemiological and virological part. For epidemiological evidence, they summarized four points: ț The geographic distribution of infection with the virus should be similar to that of the tumor with which it is associated when adjusted for the age of infection and the presence of co-factors known to be important in tumor development.

36 3 Tumors Linked to Infections: Some General Aspects xenotransplantation of these cells into nude mice, however, cell growth ceases and transcription of viral DNA is drastically reduced. In contrast to HPV-containing malignant cells, HPV-immortalized cells fail to form tumors under these conditions and persist for long periods of time as small nodules. Malignant cells commonly grow as xenotransplant and do not reveal any inhibition of viral oncogene transcription. , 1999). , 1999, 2000). Malignant HeLa cells, containing HPV 18 DNA, reveal at the same site c-jun/c-fos heterodimers.

Bring indisputable evidence for or against the cause and effect hypothesis and none can be required as a sine qua non”. In 1990, Evans and Mueller based their criteria for an etiological relationship between virus infection and tumor development more on immunological aspects, in part influenced by a previous publication by Rivers (1937). They subdivided their “. . guidelines for relating a putative virus to human cancers” into an epidemiological and virological part. For epidemiological evidence, they summarized four points: ț The geographic distribution of infection with the virus should be similar to that of the tumor with which it is associated when adjusted for the age of infection and the presence of co-factors known to be important in tumor development.

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Infections Causing Human Cancer by Harald zur Hausen


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