By Didier Rognan, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers
G protein-coupled receptors (GPCRs) are probably the most vital aim periods in pharmacology and are the objective of many blockbuster medications. but merely with the new elucidation of the rhodopsin constitution have those receptors develop into amenable to a rational drug layout.
in keeping with contemporary examples from academia and the pharmaceutical undefined, this ebook demonstrates the right way to follow the total diversity of bioinformatics, chemoinformatics and molecular modeling instruments to the rational layout of novel medicinal drugs focusing on GPCRs.
crucial analyzing for medicinal chemists and drug designers operating with this biggest type of drug objectives within the human genome.
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Ligand Design for G Protein-coupled Receptors by Didier Rognan, Raimund Mannhold, Hugo Kubinyi, Gerd Folkers