C. J. de Gara, D. B. Jones, R. H. Hunt (auth.), Alan B. R.'s Modern Concepts in Gastroenterology PDF

By C. J. de Gara, D. B. Jones, R. H. Hunt (auth.), Alan B. R. Thomson M.D., L. R. DaCosta M.D., William C. Watson M.D. (eds.)

ISBN-10: 1461290023

ISBN-13: 9781461290025

ISBN-10: 1461317894

ISBN-13: 9781461317890

A advantageous crew of state of the art researcher/clinicians who recognize their fields, have contributed to the development of data, and are able to pass judgement on what's actually very important have right here pooled their strategies in a chain of chapters at the slicing edges of gastroenterology. 4 attributes render this quantity improved to different update-oriented courses. the 1st extraordinary characteristic, that is instantly obvious upon scanning the desk of contents, is the creative number of topics, starting from trav­ eler's diarrhea and sexually transmitted GI infections via TPN and interventional endoscopy to geriatrics and iatrogenic affliction. A moment striking characteristic of this quantity is its good fortune in balanc­ ing simple pathophysiology with sensible concerns of scientific guy­ agement. this is often accomplished within the discussions of such assorted themes as acid-peptic ailments, infectious and different diarrheal syndromes, and hep­ atitis immunization. in the course of the booklet we're led easily from easy technological know-how ideas to express thoughts for analysis and treatment. This useful emphasis seems again and again and occasionally professional­ duces a pleasant shock, akin to a bankruptcy on radiology that's not tech­ nology-based yet as a substitute problem-oriented.

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Ranitidine, is 5-8 times more potent than cimetidine on an equimolar basis, allowing a twice-daily dose of 150 mg to be used. Ranitidine is consistently better than placebo in duodenal ulcer healing, all 20 trials showing a significant advantage (54-100% healing for ranitidine compared to 8-52% for placebo). " There have been 12 studies of cimetidine versus ranitidine in duodenal ulcer disease. Of the 12 trials 11 favor ranitidine (this fact alone is statistically significant). 05). A recent clinical pharmacological study of ranitidine, 300 mg at night,137 showing a superior reduction in nocturnal acid secretion to conventional twice-daily administration has led to a five-center therapeutic trial conducted in the United Kingdom and Canada ofranitidine, 300 mg at night versus 150 mg twice daily in duodenal ulcer healing.

David Fromm 1. INTRODUCTION As technical details and acid secretory consequences of the various operative procedures for peptic ulcer disease became better understood in the 1950s and 1960s, greater emphasis was placed on determining the incidence of dumping and other long-term sequelae of peptic ulcer surgery. The frequency of various syndromes occurring after gastrectomy and/or vagotomy ranged from practically none to uniform occurrence. These figures were used to support employment of one operation over others, but agreement was far from uniform.

In four prospective studies, 3the incidence of recurrent ulcer ranged from 7 to 10% after vagotomy with drainage. This is in contrast to a 1-4% incidence after vagotomy with antrectomy and a 2-5% incidence after subtotal gastrectomy. 3 Although some data suggest otherwise,9 it is generally accepted that the incidence of recurrent ulcer is least after vagotomy with antrectomy. 14 Although it is clear that residual antral mucosa in the duodenal stump of a Billroth II reconstruction places the patient at great risk for the recurrent ulcer, the role of residual antrum in the gastric stump is not clear.

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Modern Concepts in Gastroenterology by C. J. de Gara, D. B. Jones, R. H. Hunt (auth.), Alan B. R. Thomson M.D., L. R. DaCosta M.D., William C. Watson M.D. (eds.)


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