Download e-book for kindle: Mutagenic Effects of Environmental Contaminants by H. Eldon Sutton

By H. Eldon Sutton

ISBN-10: 0126779503

ISBN-13: 9780126779509

ISBN-10: 0323160107

ISBN-13: 9780323160100

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Extra resources for Mutagenic Effects of Environmental Contaminants

Example text

P. Baetcke, D. L. Shaver, and V. Pond (1968). Genetics, 59, 65. Stadler, D. (1966). Genetics, 5|*, 677. Whitfield, H. , R. G. Martin, and Β. N. Ames (1966). J. Mol . , 21_, 335. / ι 9 55 A BACTERIAL SYSTEM FOR DETECTING MUTAGENS AND CARCINOGENS* Bruce Ν. Ames It is generally agreed that it is extremely important to minimize exposure of the human gene pool to mutagens. The problems of testing mutagens are in many ways fundamentally different from those of the usual toxicological and pharmacological tests, in part because mutagenesis must be monitored in the descendents of large populations.

1970). In Current Topics i η Rad i at ion Research. Amsterdam, North Holland Pub. Co. 38 MUTAGENIC EFFECTS OF E N V I R O N M E N T A L CONTAMINANTS Rohrborn, G. (1968). Ρroc. Int. Congr. Genetics, Tokyo, 1, 103. Russell, W. L. (1951). Cold Spring Harbor Symp. Quant. , 16, 3 2 7 . Russell, W. L. (1967T. Brookhaven Symp. , 20, 179. Russell, W. , and R. B. Cumming (1971). EMS 2nd Ann. , Abstract No. 3. Sega, G. , and W. R. Lee (1970). Genetics, 6*», 558. Shankel, D. M. ( 1 9 6 2 ) . J. , 8 4 , 410.

Thus the production of recessive lethal mutations at this locus, both by gene mutation and by chromosome breakage and deletion, can be detected. This is a simple test system which can be used for routine screening and which is capable of detecting a broad spectrum of genetic damage. There is not yet any simple way to distinguish the recessive lethal mutations resulting from gene mutations from those resulting from chromosome deletion. Thus, although a heterokaryon heterozygous for mtr is theoretically capable of detecting all types of genetic damage, no characterization of the mtr mutants is possible.

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Mutagenic Effects of Environmental Contaminants by H. Eldon Sutton


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