Download e-book for iPad: NMR Spectroscopy in Pharmaceutical Analysis by Iwona Wawer, Bernd Diehl, Ulrike Holzgrabe

By Iwona Wawer, Bernd Diehl, Ulrike Holzgrabe

ISBN-10: 0444531734

ISBN-13: 9780444531735

For nearly a decade, quantitative NMR spectroscopy (qNMR) has been validated as important device in drug research. In all disciplines, i. e. drug identity, impurity profiling and assay, qNMR can be used.
Separation thoughts reminiscent of excessive functionality liquid chromatography, fuel chromatography, great fluid chromatography and capillary electrophoresis options, govern the purity review of substances. even though, those suggestions should not consistently in a position to clear up the analytical difficulties usually leading to inadequate tools. however such equipment locate their manner into foreign pharmacopoeias. hence, the purpose of the publication is to explain the chances of qNMR in pharmaceutical research.
Beside the creation to the actual basics and strategies the rules of the applying in drug research are defined: caliber assessment of gear, polymer characterization, ordinary items and corresponding reference compounds, metabolism, and stable section NMR spectroscopy for the characterization drug elements, e.g. the water content material, polymorphism, and drug formulations, e.g. drugs, powders. This half is followed by means of extra detailed chapters facing consultant examples. they offer extra targeted info via concrete examples.

• combines idea, concepts, and urban applications―all of which heavily resemble the laboratory event
• considers overseas pharmacopoeias, addressing the worry for licensing
• positive factors the paintings of teachers and researchers, attractive to a huge readership

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NMR Spectroscopy in Pharmaceutical Analysis by Iwona Wawer, Bernd Diehl, Ulrike Holzgrabe


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